Article

Non-negative Independent Factor Analysis disentangles discrete and continuous sources of variation in scRNA-seq data

2020-02-02

Abstract excerpt

<h4>Motivation</h4> Single-cell RNA-seq analysis has emerged as a powerful tool for understanding inter-cellular heterogeneity. Due to the inherent noise of the data, computational techniques often rely on dimensionality reduction (DR) as both a pre-processing step and an analysis tool. Ideally, dimensionality reduction should preserve the biological information while discarding the noise. However if the dimensio...

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Literature Corpus work: 36d00e74-e50d-5386-a9d2-7c9235a9b344
DOI: 10.1101/2020.01.31.927921

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