Article

COMPASS enables cohort-independent digital biomarker discovery and pathway quantification

2025-12-03

Abstract excerpt

Reproducible and clinically transferable quantification of pathway activity remains a major barrier in precision medicine, where biomarker performance often depends on cohort composition and normalization strategies. Here, we introduce COMPASS ( COMP osite A ctivity S coring S ystem), a deterministic threshold-based framework that converts gene expression into quantitative pathway activity scores without relia...

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Literature Corpus work: abda0183-a445-56ee-aa98-3f7b88ba8bd6
DOI: 10.64898/2025.12.02.687315

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