Article

NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli

2022-01-16

Abstract excerpt

Many scenarios in cellular communication requires cells to interpret multiple dynamic signals. It is unclear how exposure to immune stimuli alters transcriptional responses to subsequent stimulus under inflammatory conditions. Using high-throughput microfluidic live cell analysis, we systematically profiled the NF-κB response to different signal sequences in single cells. We found that NF-κB dynamics stores the hi...

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Literature Corpus work: edf46d86-207f-5227-96c5-17d576de1951
DOI: 10.1101/2022.01.14.476099

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