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Article

FSHD myotubes with different phenotypes exhibit distinct proteomes.

PloS one - 1 Jan 2012

Tassin Alexandra, Leroy Baptiste, Laoudj-Chenivesse Dalila, Wauters Armelle, Vanderplanck Céline, Le Bihan Marie-Catherine, Coppée Frédérique, Wattiez Ruddy, Belayew Alexandra

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is a progressive muscle disorder linked to a contraction of the D4Z4 repeat array in the 4q35 subtelomeric region. This deletion induces epigenetic modifications that affect the expression of several genes located in the vicinity. In each D4Z4 element, we identified the double homeobox 4 (DUX4) gene. DUX4 expresses a transcription factor that plays a major role in the...

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Identifiers

PMID: 23272181
DOI: 10.1371/journal.pone.0051865
PMCID: PMC3525578

Genes

DUX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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