Article

Single-myofiber RNA-sequencing reveals myofiber-level transcriptomic heterogeneity and DUX4 activation in FSHD muscle biopsies

2025-10-16

Abstract excerpt

<title>Abstract</title> <p>Although expression of the transcription factor DUX4 in skeletal muscle is widely regarded as the primary driver of facioscapulohumeral muscular dystrophy (FSHD), its assumed sporadic and transient nature complicates full characterization of its transcriptional impact. Cellular heterogeneity within FSHD muscles remains only partially understood. Here, we applied single-myofiber RNA-sequ...

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Literature Corpus work: 358c81c0-6e09-5935-b591-1c0fe0a128d5
DOI: 10.21203/rs.3.rs-7715788/v1

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