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Article

Facioscapulohumeral Muscular Dystrophy is Associated With Altered Myoblast Proteome Dynamics

21 Jun 2023

Abstract excerpt

O) labeling and peptide mass spectrometry to investigate the abundance and turnover rates of proteins in cultured muscle cells from two individuals affected by FSHD and their unaffected siblings (UASb). We measured the abundance of 4420 proteins and the turnover rate of 2324 proteins in each (n = 4) myoblast sample. FSHD myoblasts exhibited a greater abundance but slower turnover rate of subunits of mitochondrial...

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PMID: 37353005
DOI: 10.1016/j.mcpro.2023.100605

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