Article

Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei

2018-11-27

Abstract excerpt

FSHD is characterized by the misexpression of DUX4 in skeletal muscle. However, DUX4 is lowly expressed in patient samples and analysis of the consequences of DUX4 expression has largely relied on artificial overexpression. To better understand the native expression profile of DUX4 and its targets, we performed pooled RNA-seq differentiation time-course in FSHD2 patient-derived primary myoblasts and identified...

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Literature Corpus work: 97bc020b-8866-5bd5-9093-5775cd16f758
DOI: 10.1101/478636

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