Article

Posttranslational modifications of the DUX4 protein impact toxic function

2022-07-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Facioscapulohumeral muscular dystrophy (FSHD) is caused by abnormal de-repression of the transcription factor DUX4, which is toxic to muscle in vitro and in vivo . While the transcriptional targets of DUX4 are known, the regulation of DUX4 protein and the molecular consequences of this regulation are unclear. Here, we used in vitro models of FSHD to identify and characteri...

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Literature Corpus work: 61de00ea-f941-5b2e-b1ed-cbb244787059
DOI: 10.1101/2022.07.22.501148

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