Article

Borrowing Transcriptional Kinases to Activate Apoptosis

2023-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Protein kinases are disease drivers whose therapeutic targeting traditionally centers on inhibition of enzymatic activity. Here chemically induced proximity is leveraged to convert kinase inhibitors into context-specific activators of therapeutic genes. Bivalent molecules that link ligands of the transcription factor B-cell lymphoma 6 (BCL6) to ATP-competitive inhibitors of cyclin-dependent kina...

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Identifiers and source

Literature Corpus work: 372f4833-eb91-5d25-b7fa-09ff74fbb2c8
DOI: 10.1101/2023.10.23.563687

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