Article

Leveraging the BAF chromatin remodeling complex for targeted transcriptional rewiring in cancer

2026-04-01

Abstract excerpt

Chromatin accessibility is essential for maintaining the fidelity of gene regulation and is dynamically regulated by epigenetic enzymes that are often dysregulated in cancer. The most commonly mutated regulator is the modular, multi-subunit Brahma-associated factor (BAF) chromatin remodeling complex. Previous attempts to exploit BAF complex mutations as potential tumor vulnerabilities using loss-of-function approa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c95b846-fe7c-5ff8-8ee7-cdab6c611bd3
DOI: 10.64898/2026.03.30.715217

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging the BAF chromatin remodeling complex for targeted transcriptional rewiring in cancerDOI 10.64898/2026.03.30.715217Read

Hijacking the transcriptional activation potential of the BAF complex via Induced ProximitySemantic proximity Read

Borrowing Transcriptional Kinases to Activate ApoptosisSemantic proximity Read

Rewiring Cancer Drivers to Activate ApoptosisSemantic proximity Read

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphomaSemantic proximity Read

The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer.Semantic proximity Read

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancersSemantic proximity Read

The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain.Semantic proximity Read

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and BeyondSemantic proximity Read

The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and BromodomainSemantic proximity Read

Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomasSemantic proximity Read

An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regionsSemantic proximity Read

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancersSemantic proximity Read