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Article

Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.

Journal of the American Chemical Society - 12 Jul 2023

Kabir Md, Sun Ning, Hu Xiaoping, Martin Tiphaine C, Yi Jingjie, Zhong Yue, Xiong Yan, Kaniskan H Ümit, Gu Wei, Parsons Ramon, Jin Jian

Abstract excerpt

With advances in chemically induced proximity technologies, heterobifunctional modalities such as proteolysis targeting chimeras (PROTACs) have been successfully advanced to clinics for treating cancer. However, pharmacologic activation of tumor-suppressor proteins for cancer treatment remains a major challenge. Here, we present a novel Acetylation Targeting Chimera (AceTAC) strategy to acetylate the p53 tumor...

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Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 37365684
DOI: 10.1021/jacs.3c04640
PMCID: PMC10357929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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