Article

Rewiring DNA repair with PARP-based chemical inducers of proximity

2025-07-31

Abstract excerpt

Chemical inducers of proximity (CIPs) can elicit durable—and often neomorphic—biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This “event-driven” pharmacology is exemplified by CIPs that promote targeted protein degradation, but other applications remain underexplored. We developed a generalizable strategy to discover event-driven CIPs by tracking...

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Literature Corpus work: 9cc38bfb-3eca-5a6e-9fbc-ca708335157b
DOI: 10.1101/2025.07.26.666954

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