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Article

Modulation of autophagic activity by extracellular pH

1 Nov 2011

Abstract excerpt

Reprogramming energy metabolism from oxidative phosphorylation to aerobic glycolysis, a common feature of human cancer, is associated with a relative acidic tumor microenvironment which can sometimes be further accentuated by hypoxia operating within most solid tumors. We found that alteration of extracellular pH induces marked and rapid changes of autophagic activity. Interestingly, acidic and basic conditions...

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Identifiers

PMID: 21997366
DOI: 10.4161/auto.7.11.17785

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