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Article

Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes.

Journal of medical genetics - 1 Apr 2014

Docherty Louise E, Rezwan Faisal I, Poole Rebecca L, Jagoe Hannah, Lake Hannah, Lockett Gabrielle A, Arshad Hasan, Wilson David I, Holloway John W, Temple I Karen, Mackay Deborah J G

Abstract excerpt

BACKGROUND: Genomic imprinting is allelic restriction of gene expression potential depending on parent of origin, maintained by epigenetic mechanisms including parent of origin-specific DNA methylation. Among approximately 70 known imprinted genes are some causing disorders affecting growth, metabolism and cancer predisposition. Some imprinting disorder patients have hypomethylation of several imprinted loci...

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Identifiers

PMID: 24501229
DOI: 10.1136/jmedgenet-2013-102116
PMCID: PMC3963529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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