Article

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

2019-08-24

Abstract excerpt

<h4>SUMMARY</h4> Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Here, we demonstrate that manipulating PGRMC1 phosphorylation status in MIA PaCa-2 (MP) cells imposes broad pleiotropic ef...

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Literature Corpus work: 36ee0f94-bb52-57af-8020-30664c653021
DOI: 10.1101/737718

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