Article
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Science signaling - 17 Nov 2009
Hitosugi Taro, Kang Sumin, Vander Heiden Matthew G, Chung Tae-Wook, Elf Shannon, Lythgoe Katherine, Dong Shaozhong, Lonial Sagar, Wang Xu, Chen Georgia Z, Xie Jianxin, Gu Ting-Lei, Polakiewicz Roberto D, Roesel Johannes L, Boggon Titus J, Khuri Fadlo R, Gilliland D Gary, Cantley Lewis C, Kaufman Jonathan, Chen Jing
Abstract excerpt
The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose even in the presence of oxygen. To better understand how tyrosine kinase signaling, which is commonly increased in tumors, regulates the Warburg effect, we performed phosphoproteomic studies. We found that oncogenic forms of fibroblast growth...
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