Article

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

2020-03-05

Abstract excerpt

<title>Abstract</title> <p>Background: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. <h4>Results:</h4> We demonstrate that manipulating PGRMC1 phosphorylation status in MIA PaCa-2 (MP)...

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Literature Corpus work: c0721e65-6dda-5ca9-8887-c32162fc2d81
DOI: 10.21203/rs.2.22342/v3

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