Article
[The Warburg effect: from theory to therapeutic applications in cancer].
Medecine sciences : M/S - 1 Nov 2013
Razungles Julie, Cavaillès Vincent, Jalaguier Stéphan, Teyssier Catherine
Abstract excerpt
Cancer cell metabolism described by Otto Warburg in the thirties became a cancer specific hallmark, also called "Warburg effect". Cancer cells use essentially glucose as fuel, through glycolysis, in order to meet their energy and biomass needs to insure their cell proliferation. Recent advances describe Warburg effect regulation by oncogenes and tumor suppressor genes. Moreover, mutations in some glycolysis...
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