Article
PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease.
BMC molecular and cell biology - 15 Apr 2020
Thejer Bashar M, Adhikary Partho P, Teakel Sarah L, Fang Johnny, Weston Paul A, Gurusinghe Saliya, Anwer Ayad G, Gosnell Martin, Jazayeri Jalal A, Ludescher Marina, Gray Lesley-Ann, Pawlak Michael, Wallace Robyn H, Pant Sameer D, Wong Marie, Fischer Tamas, New Elizabeth J, Fehm Tanja N, Neubauer Hans, Goldys Ewa M, Quinn Jane C, Weston Leslie A, Cahill Michael A
Abstract excerpt
BACKGROUND: Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently with the embryological gastrulation organizer that orchestrates vertebrate tissue differentiation. RESULTS: Here, we show that mutagenic manipulation of PGRMC1 phosphorylation alters cell...
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