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Article

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.

Molecular cell - 3 Mar 2016

Li Xinjian, Jiang Yuhui, Meisenhelder Jill, Yang Weiwei, Hawke David H, Zheng Yanhua, Xia Yan, Aldape Kenneth, He Jie, Hunter Tony, Wang Liwei, Lu Zhimin

Abstract excerpt

It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that hypoxia, EGFR activation, and expression of K-Ras G12V and B-Raf V600E induce mitochondrial translocation of phosphoglycerate kinase 1 (PGK1); this is mediated by ERK-dependent PGK1 S203 phosphorylation and subsequent PIN1-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26942675
DOI: 10.1016/j.molcel.2016.02.009
PMCID: PMC4888784

Genes

PGK1
EGFR
PIN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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