Article

<i>VEGFR3</i> gene structure, regulatory region, and sequence polymorphisms

2001-04-01

Abstract excerpt

ABSTRACT Vascular endothelial growth factor receptor 3 (VEGFR‐3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed in lymphatic endothelial cells, and mutant VEGFR3 alleles have been implicated in human hereditary lymphedema. To better understand the basis of its specific endothelial lineage‐restricted expression, we have characterized the VEGFR3 gene and its re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36de7f28-2cfb-5abf-bf69-873e61100116
DOI: 10.1096/fsb2fj000383com

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>VEGFR3</i> gene structure, regulatory region, and sequence polymorphismsDOI 10.1096/fsb2fj000383comRead

VEGFR3 gene structure, regulatory region, and sequence polymorphisms.Semantic proximity Read

The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases.Semantic proximity Read

Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase.Semantic proximity Read

Identification of a novel VEGFR-3 missense mutation in a Chinese family with hereditary lymphedema type I.Semantic proximity Read

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3Semantic proximity Read

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.Semantic proximity Read

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expressionSemantic proximity Read

<i>Vegfr3</i> is required in the <i>Tbx1</i> expression domain for cardiac outflow tract developmentSemantic proximity Read

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.Semantic proximity Read

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesisSemantic proximity Read

Molecular control of lymphangiogenesisSemantic proximity Read

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.Semantic proximity Read