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Article

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.

Nature genetics - 1 Jun 2000

Karkkainen M J, Ferrell R E, Lawrence E C, Kimak M A, Levinson K L, McTigue M A, Alitalo K, Finegold D N

Abstract excerpt

Primary lymphoedema is a rare, autosomal dominant disorder that leads to a disabling and disfiguring swelling of the extremities and, when untreated, tends to worsen with time. Here we link primary human lymphoedema to the FLT4 locus, encoding vascular endothelial growth factor receptor-3 (VEGFR-...

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Source

Identifiers

PMID: 10835628
DOI: 10.1038/75997

Genes

FLT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10835628-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.PMID 10835628Read ↗

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