Article
VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2001
Iljin K, Karkkainen M J, Lawrence E C, Kimak M A, Uutela M, Taipale J, Pajusola K, Alhonen L, Halmekytö M, Finegold D N, Ferrell R E, Alitalo K
Abstract excerpt
Vascular endothelial growth factor receptor 3 (VEGFR-3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed in lymphatic endothelial cells, and mutant VEGFR3 alleles have been implicated in human hereditary lymphedema. To better understand the basis of its specific endothelial lineage-restricted expression, we have characterized the VEGFR3 gene and its regulatory...
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