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Article

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

19 Oct 2007

Abstract excerpt

The Notch family of cell surface receptors and its ligands are highly conserved proteins that regulate cell fate determination, including those involved in mammalian vascular development. We report that Notch induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice. In vitro, Notch in complex with the DNA-binding protein CBF-1/suppressor of hairless/Lag1 (CSL) bound the VEGFR-3 promoter...

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PMID: 17948123
DOI: 10.1172/jci24311

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