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Article

The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases.

Cardiovascular research - 7 Jul 2021

Monaghan Richard M, Page Donna J, Ostergaard Pia, Keavney Bernard D

Abstract excerpt

Vascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily conserved VEGF signalling pathways that regulate the development and maintenance of the body's cardiovascular and lymphovascular systems. VEGFR3, encoded by the FLT4 gene, has an indispensable and well-characterized function in development and establishment of the lymphatic system. Autosomal dominant VEGFR3 mutations, that...

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Share to Cardiovascular System
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Lymphatic System

Share to Lymphedema

Share to Mice, Transgenic

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Share to Vascular Endothelial Growth Factor Receptor-3

Source

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Identifiers

PMID: 33067626
DOI: 10.1093/cvr/cvaa291
PMCID: PMC8262640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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