Article
Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression.
Cell communication and signaling : CCS - 22 Oct 2019
Duan Biao, Liu Yan, Hu He, Shi Fu-Guo, Liu Ya-Long, Xue Hao, Yun Xin-Yu, Yan Ming-Yu, Han Xi-Rui, Chen An-Fu, Wang Yong, Li Zhe-Hai
Abstract excerpt
BACKGROUND: Osteoarthritis (OA) is one of the most prevalent joint disease, and there are still no effective therapeutic agents or clinical methods for the cure of this disease to date. The degradation of cartilage extracellular matrix (ECM) is a major cause of OA. METHOD: IL-1β was used to induce chondrogenic degradation. Q-PCR and Western blotting were used to detect mRNA and protein level, respectively. ELISA...
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