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Article

Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NF-κB signaling pathway.

Oncotarget - 18 Jul 2017

Huang Yao, Chen Jian, Jiang Tao, Zhou Zheng, Lv Bin, Yin Guoyong, Fan Jin

Abstract excerpt

This study investigated the inhibitory effect of gallic acid (GA) on the release of A Disintegrin and Metalloproteinase with Thrombospondin motifs 4 (ADAMTS4) through the regulation of the NF-κB signaling pathway, which is closely related to the matrix metalloproteinases in nucleus pulposus cells. Different concentrations of GA were added to TNF-α-induced human nucleus pulposus cells (hNPCs) and intervertebral...

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Source

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Identifiers

PMID: 28512264
DOI: 10.18632/oncotarget.17509
PMCID: PMC5564596

Genes

TNF
ADAMTS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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