Article
Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: In silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain.
PLoS computational biology - 1 Dec 2025
Sacco Monica, Lancellotti Stefano, Ferretti Antonietta, Basso Maria, Di Gennaro Leonardo, Castaman Giancarlo, De Cristofaro Raimondo
Abstract excerpt
Type 1 von Willebrand disease (VWD) is often caused by variants in von Willebrand factor (VWF), including p.R1205H ("Vicenza mutation"), which accelerate VWF clearance via macrophage receptor LRP1 and impair platelet adhesion and activation. However, the structural mechanisms underlying these phenotypes remain partially unclear. Here, we use integrative computational modeling (I-TASSER, HADDOCK2.4, and PRODIGY)...
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