Article
Positive selection at the protein network periphery: evaluation in terms of structural constraints and cellular context.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2007
Kim Philip M, Korbel Jan O, Gerstein Mark B
Abstract excerpt
Because of recent advances in genotyping and sequencing, human genetic variation and adaptive evolution in the primate lineage have become major research foci. Here, we examine the relationship between genetic signatures of adaptive evolution and network topology. We find a striking tendency of proteins that have been under positive selection (as compared with the chimpanzee) to be located at the periphery of the...
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