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Mammalian Base Excision Repair: the Forgotten Archangel

12 Feb 2013

Abstract excerpt

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of...

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PMID: 23408852
DOI: 10.1093/nar/gkt076

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