Article

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model

2022-08-27

Abstract excerpt

<h4>SUMMARY</h4> Accumulation of advanced glycation end products (AGEs) on biopolymers accompany cellular aging and drives poorly understood disease processes. Here, we studied how AGEs contribute to development of early on-set Parkinson’s Disease (PD) caused by loss-of-function of DJ1, a protein deglycase. In induced pluripotent stem cell (iPSC)-derived midbrain organoid models deficient for DJ1 activity, we fin...

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Literature Corpus work: 36cd9cf9-b087-5076-9f8d-f81c07aef9cb
DOI: 10.1101/2022.08.26.505472

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