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Article

Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease

22 Jul 2019

Abstract excerpt

This article describes pathogenic concepts and factors, in particular glycolipid abnormalities, that create cell dysfunction and synaptic loss in neurodegenerative diseases. By phenocopying lysosomal storage disorders, such as Gaucher disease and related disorders, age- and dose-dependent changes in glycolipid cell metabolism can lead to Parkinson's disease and related dementias. Recent results show that...

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PMID: 31331333
DOI: 10.1186/s12974-019-1532-2

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