Article

Glucocerebrosidase Deficiency Dysregulates Human Astrocyte Lipid Metabolism

2025-01-13

Abstract excerpt

<h4>Background: </h4> Deficiency in the lysosomal enzyme, glucocerebrosidase (GCase), caused by mutations in the GBA1 gene, is the most common genetic risk factor for Parkinson's disease (PD). However, the consequence of reduced enzyme activity within neural cell sub-types remains ambiguous. Thus, the purpose of this study was to define the effect of GCase deficiency specifically in human astrocytes and test their...

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Literature Corpus work: af8c9324-d099-5203-8e81-3aff7c660745
DOI: 10.1101/2025.01.09.632210

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