Article

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation

2022-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Protein S-acylation is a reversible post-translational modification that modulates the localisation and function of many cellular proteins. S-acylation is mediated by a family of zinc finger DHHC domain-containing proteins encoded by 23 distinct ZDHHC genes in the human genome. These enzymes catalyse S-acylation in a two-step process involving “auto-acylation” of the cysteine residue in the cat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36c915d8-846d-5c2d-8fbc-9cf1dd7137e4
DOI: 10.1101/2022.03.17.484726

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylationDOI 10.1101/2022.03.17.484726Read

A palmitoyl transferase chemical genetic system to map ZDHHC-specific <i>S</i> -acylationSemantic proximity Read

New links between <i>S</i>‐acylation and cancerSemantic proximity Read

Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.Semantic proximity Read

A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification.Semantic proximity Read

Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.Semantic proximity Read

Structure and function of DHHC protein S-acyltransferases.Semantic proximity Read

ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.Semantic proximity Read

Cutting out the fat: Site-specific deacylation of an ion channel.Semantic proximity Read

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.Semantic proximity Read

S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac HypertrophySemantic proximity Read

The S-palmitoylome and DHHC-PAT interactome of <i>Drosophila melanogaster</i> S2R+ cells indicate a high degree of conservation to mammalian palmitoylomesSemantic proximity Read

Evolved, Selective Erasers of Distinct Lysine AcylationsSemantic proximity Read