Article
The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.
Molecular biology of the cell - 1 Dec 2014
Lemonidis Kimon, Gorleku Oforiwa A, Sanchez-Perez Maria C, Grefen Christopher, Chamberlain Luke H
Abstract excerpt
S-acylation, the attachment of fatty acids onto cysteine residues, regulates protein trafficking and function and is mediated by a family of zDHHC enzymes. The S-acylation of peripheral membrane proteins has been proposed to occur at the Golgi, catalyzed by an S-acylation machinery that displays little substrate specificity. To advance understanding of how S-acylation of peripheral membrane proteins is handled by...
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