Article
ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.
Molecular and cellular biology - 1 Sept 2016
Lievens Patricia Marie-Jeanne, Kuznetsova Tatiana, Kochlamazashvili Gaga, Cesca Fabrizia, Gorinski Natalya, Galil Dalia Abdel, Cherkas Volodimir, Ronkina Natalia, Lafera Juri, Gaestel Matthias, Ponimaskin Evgeni, Dityatev Alexander
Abstract excerpt
The neural cell adhesion molecule (NCAM) mediates cell-cell and cell-matrix adhesion. It is broadly expressed in the nervous system and regulates neurite outgrowth, synaptogenesis, and synaptic plasticity. Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing...
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