Article

Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42

2017-11-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> The common colon-26 mouse (C-26) model of experimental cachexia mimics recent late stage clinical failures of anabolic anti-cachexia therapy, and does not respond to the anabolic selective androgen receptor modulator (SARM) GTx-024. Based on the demonstrated anti-cachectic efficacy of the histone deacetylase inhibitor (HDACi) AR-42 in this model, we hypothesized that combined S...

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Literature Corpus work: 36c8c772-a956-5ee2-8adb-f8c55d9ba20c
DOI: 10.1101/214155

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