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Article

A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle.

The EMBO journal - 1 Mar 2022

Morikawa Manatsu, Jerath Nivedita U, Ogawa Tadayuki, Morikawa Momo, Tanaka Yosuke, Shy Michael E, Zuchner Stephan, Hirokawa Nobutaka

Abstract excerpt

The mechanochemical coupling of ATPase hydrolysis and conformational dynamics in kinesin motors facilitates intramolecular interaction cycles between the kinesin motor and neck domains, which are essential for microtubule-based motility. Here, we characterized a charge-inverting KIF1A-E239K mutant that we identified in a family with axonal-type Charcot-Marie-Tooth disease and also in 24 cases in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35132656
DOI: 10.15252/embj.2021108899
PMCID: PMC8886545

Genes

KIF1A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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