Article

KIF1A neurodegenerative disease mutations modulate motor motility and force generation

2023-06-10

Abstract excerpt

KIF1A is involved in fast axonal transport of synaptic vesicle precursor, neurofilament, and dense-core vesicle, essential for neuronal development and maintenance. Several point mutations in the KIF1A motor domain have been identified in patients with various motor neuron diseases. Recent studies have shown that these mutations affected the motor and cargo localization in cultured hippocampal and C.elegans neuro...

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Literature Corpus work: f83f736e-7e4a-53e1-bb72-4833a07bdd01
DOI: 10.1101/2023.06.09.544228

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