Article

Divergent Redox-Resilience of Alvelestat and Sivelestat: A Mechanistic Hypothesis for Inhibitor Performance Under Oxidative Stress

2026-03-26

Abstract excerpt

Human neutrophil elastase (HNE) is a key driver of inflammatory lung disorders, pro-moting extracellular matrix degradation and tissue damage. While inhibitors such as Sivelestat and Alvelestat are clinically relevant, their performance within the aggressive oxidative microenvironment of diseased lungs remains poorly understood. Here, we employed an integrated in vitro and in silico approach to investigate their b...

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Literature Corpus work: 369de267-b475-584a-800b-33bc19cec702
DOI: 10.20944/preprints202603.2137.v1

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