Article

Unique structural and ligand binding properties of the <i>Staphylococcus aureus</i> serine hydrolase FphE

2025-10-12

Abstract excerpt

Staphylococcus aureus is a human pathogen capable of forming biofilms that complicate treatment and facilitate chronic infections. A family of S. aureus serine hydrolases are important regulators of virulence and biofilm formation. Among these, FphE is highly specific to S. aureus and therefor a viable target for both imaging and therapy. Here, we present bioinformatic and structural evidence that FphE may be in...

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Literature Corpus work: 27df6985-6f2c-5c14-b7b9-fdecdd870634
DOI: 10.1101/2025.10.12.681921

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