Article

Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery

2021-09-02

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is a multifunctional immunoregulatory protein that is a key player in the innate immune response. Given its overexpression at sites of inflammation in a wide range of diseases marked by increasingly oxidative cellular environment, a comprehensive structural understanding of how cellular redox conditions may impact the structure and function of MIF is necessary. We used...

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Literature Corpus work: 2aa3d235-dcc1-52cd-85d6-a7470d2b2777
DOI: 10.1101/2021.09.01.458630

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