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Article

Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.

The FEBS journal - 1 Apr 2025

Gangemi Roberto, Bignotti Mattia, Denardo Andrea, Pearce Claudia N, Ronzoni Riccardo, Lomas David A, Irving James A, Fra Annamaria, Gangemi Fabrizio

Abstract excerpt

Neutrophil elastase (NE) is released by activated neutrophils during an inflammatory response and exerts proteolytic activity on elastin and other extracellular matrix components. This protease is rapidly inhibited by the plasma serine protease inhibitor alpha-1-antitrypsin (AAT), and the importance of this protective activity on lung tissue is highlighted by the development of early onset emphysema in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39777987
DOI: 10.1111/febs.17387
PMCID: PMC12001179

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