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Article

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Nature chemical biology - 1 Nov 2008

Garcin Elsa D, Arvai Andrew S, Rosenfeld Robin J, Kroeger Matt D, Crane Brian R, Andersson Gunilla, Andrews Glen, Hamley Peter J, Mallinder Philip R, Nicholls David J, St-Gallay Stephen A, Tinker Alan C, Gensmantel Nigel P, Mete Antonio, Cheshire David R, Connolly Stephen, Stuehr Dennis J, Aberg Anders, Wallace Alan V, Tainer John A, Getzoff Elizabeth D

Abstract excerpt

Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low concentrations and a defensive cytotoxin at higher concentrations. The high active site conservation among all three NOS isozymes hinders the design of selective NOS inhibitors to...

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Identifiers

PMID: 18849972
DOI: 10.1038/nchembio.115
PMCID: PMC2868503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18849972-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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