Article

DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

2022-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly heterogeneous, it has been challenging to use affected genes to predict tumour aggressiveness, metastatic evolution, and patients’ outcomes. We hypothesized that common aggressive hypermethylation signatures should emerge early in tumorigenesis an...

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Literature Corpus work: f47d0799-c75c-5358-b7d9-2ad045655ed1
DOI: 10.1101/2022.04.11.487909

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