Article

Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulation

2019-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Emerging CRISPR technologies are enabling powerful new approaches to control mammalian cell functions, yet the lack of spatially-defined, noninvasive modalities to direct their function limit their potential as biological tools and pose a major challenge for clinical translation. Here we confer remote control of CRISPR-dCas9 activity using thermal gene switches, enabling the dynamic regulation o...

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Identifiers and source

Literature Corpus work: 36991262-4bcf-5e45-ad3e-bfcdfe3a1054
DOI: 10.1101/606723

Open publication

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