Article

Acoustic Remote Control of Bacterial Immunotherapy

2021-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Rapid advances in synthetic biology are driving the development of genetically engineered microbes as therapeutic agents for a multitude of human diseases, including cancer. In particular, the immunosuppressive microenvironment of solid tumors creates a favorable niche for systemically administered bacteria to engraft in the tumor and release therapeutic payloads. However, such payloads can be h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb46410c-c42f-5af7-b402-2c0e7bec88ed
DOI: 10.1101/2021.03.25.434639

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Acoustic Remote Control of Bacterial ImmunotherapyDOI 10.1101/2021.03.25.434639Read

Thermal Control of T-cell ImmunotherapySemantic proximity Read

Thermally controlled state switches for macrophage immunotherapySemantic proximity Read

Thermal Control of Engineered T-cellsSemantic proximity Read

LIFUS-Driven Engineered Bacteria Reprogram Immunosuppressive Niches via Mechano-NOTCH SignalingSemantic proximity Read

Non-invasive imaging of cell-based therapies using acoustic reporter genesSemantic proximity Read

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodiesSemantic proximity Read

Ultrasound Control of Genomic Regulatory Toolboxes for Cancer ImmunotherapySemantic proximity Read

Simulation-guided non-thermal low-intensity ultrasound reprograms the tumor immune microenvironment and engages systemic antitumor immunity in a syngeneic orthotopic mouse model of breast cancerSemantic proximity Read

Safety switches for adoptive cell therapySemantic proximity Read

Programmable bacteria induce durable tumor regression and systemic antitumor immunitySemantic proximity Read

Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulationSemantic proximity Read

In Situ Synthesis of an Immune-Checkpoint Blocker from Engineered Bacteria Elicits a Potent Antitumor ResponseSemantic proximity Read