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Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy

1 Dec 2024

Abstract excerpt

There remains a critical need for the precise control of CRISPR (clustered regularly interspaced short palindromic repeats)-based technologies. Here, we engineer a set of inducible CRISPR-based tools controllable by focused ultrasound (FUS), which can penetrate deep and induce localized hyperthermia for transgene activation. We demonstrate the capabilities of FUS-inducible CRISPR, CRISPR activation (CRISPRa), and...

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PMID: 39617755
DOI: 10.1038/s41467-024-54477-7

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