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Precision Control of CRISPR-Cas9 Using Small Molecules and Light

14 Jan 2019

Abstract excerpt

The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system is an adaptive immune system of bacteria that has furnished several RNA-guided DNA endonucleases (e.g., Cas9) that are revolutionizing the field of genome engineering. Cas9 is being used to effect genomic alterations as well as in gene drives, where a particular trait may be propagated through a targeted species population over...

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PMID: 30640437
DOI: 10.1021/acs.biochem.8b01202

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