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Prospects for the Development of Pink1 and Parkin Activators for the Treatment of Parkinson’s Disease

19 Nov 2022

Abstract excerpt

Impaired mitophagy is one of the hallmarks of the pathogenesis of Parkinson's disease, which highlights the importance of the proper functioning of mitochondria, as well as the processes of mitochondrial dynamics for the functioning of dopaminergic neurons. At the same time, the main factors leading to disruption of mitophagy in Parkinson's disease are mutations in the Pink1 and Parkin enzymes. Based on the...

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PMID: 36432705
DOI: 10.3390/pharmaceutics14112514

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